Mesoporous bioactive glasses with metallic ion and biomolecule releasing capability

 

Investigator: Qaisar Nawaz (PhD Student)Qaisar Nawaz

Ulrich-Schalk-Straße 3
91056 Erlangen

room: 01.122

phone: +49 (0)9131 85-69632

email: qaisar.nawaz@fau.de

Supervisor: Prof. Dr.-Ing. habil. Aldo R. Boccaccini




The aim of this research is to develop multifunctional mesoporous bioactive glass vehicles as therapeutic carriers of biologically active ions and biomolecules for bone regeneration applications. Such highly ordered mesoporous bioactive glass particles will be made by a template guided approach. 3D printing and form replica method will be used to fabricate 3D scaffolds of different pore architecture which will be functionalised by mesoporous particles following previous approaches developed at the Erlangen Institute of Biomaterials [1]. The novel materials will be fully characterized in order to assess its suitability for bone regeneration applications, including microstructural characterisation, testing of mechanical properties, assessment of drug release kinetics, and determination of cytocompatibility.

[1] Boccardi, E., Philippart, A., Bortuzzo, J., Beltran, A., Novarja, G., Vitale Brovarone, C., Spiecker, E., Boccaccini, A. R., Uniform surface modification of 3D Bioglass®-based scaffolds with mesoporous silica particles (MCM-41) for enhancing drug delivery capability, Front. Bioeng. Biotechnol. 3 (2015):177. doi: 10.3389/fbioe.2015.00177.