Structuring 45S5 Bioglass® surfaces by electrospun polymer fibres

 

Investigator: Sonja Kuth (Bachelor student) Sonja Kuth

 

Supeervisor: Laura Ramos Rivera, Prof. Dr.-Ing. habil. Aldo R. Boccaccin

 

The objective of this project is the fabrication and characterization of electrospun PCL (polycaprolactone) nanofibrous scaffolds on 45S5 Bioglass® pellets, following early results [1]. Fiber diameter, porosity, pore size will be studied. Bioactivity studies in simulated body fluid will be carried out to assess the effect of the fibre structure on the hydroxypatite layer formation. PCL is a synthetic biodegradable aliphatic polyester which has attracted considerable attention in recent years, notably in the biomedical areas of controlled-release drug delivery systems, absorbable surgical sutures, nerve guides, and three-dimensional (3-D) scaffolds for use in tissue engineering. To optimize the properties of the fibers for a given application PCL will be blended with other polymers.

[1] D. M. Yunos et al., Fabrication and characterization of electrospun poly-DL-lactide (PDLLA) fibrous coatings on 45S5 Bioglass® substrates for bone tissue engineering applications,  Journal of Chemical Technology & Biotechnology 85(6) (2009):768 - 774.