Fabrication and characterization of polycaprolactone-based electrospun fiber mats containing phytotherapeutic agents for wound healing


Investigator: Stefan Endlein (Bachelor student) 

Stefan Endlein


Supervisors: Irem Ünalan, Prof. Aldo R. Boccaccini

For centuries, plant-derived phytotherapeutic agents, such as essential oils have been used to treat bacterial infections due to their antiseptic and anti-inflammatory properties, making them suitable for wound healing and for bone regeneration applications. For such biomedical applications, phytotherapeutic can be incorporated into electrospun fibers made of synthetic polymers to improve the intrinsic volatility and instability of natural compounds. This bachelor thesis project aims to fabricate and characterize PCL based fiber mats incorporating natural therapeutic compounds by the electrospinning method using benign solvents [1]. A complete characterisation of the new fibres will be carried out, including the determination of their antibacterial activity.

[1] L. Liverani, A. R. Boccaccini, Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents, Nanomaterials 2016, 6(4), 75.