Fabrication of 3D chitosan-bioactive glass composite scaffolds by electrophoretic deposition

 

Investigator: Eliana Panno  (Visiting student, Polytechnic of Milan, Italy)

Eliana Panno

 

Supervisor (Milan): Prof. L. Altomare and Prof. L. De Nardo

Supervisor (FAU): Supachai Reakasame, Prof. Aldo R. Boccaccini

At the Department of Chemistry, Materials and Chemical Engineering “Giulio Natta” (Polytechnic of Milan), under the supervision of Professors Altomare and De Nardo, an optimization of the parameters affecting the uniform electrophoretic deposition (EPD) of chitosan based scaffolds containing bioactive glass particles has been carried out. The EPD technique has been largely used for covering metals with ceramic, polymeric and hybrid coatings [1], but recently it has also been investigated as an economic, simple and effective method to synthetize 3D self-standing scaffolds in the field of bone regeneration [2]. Two different bioactive glass compositions are being tested: a standard (45S5) and an innovative one containing niobium [3, 4]. Structures morphology and niobium antibacterial activity have been also evaluated. At the FAU Institute of Biomaterials, chemical-physical characterization of chitosan based, bioactive glass containing scaffolds and cell viability test are executed under the supervision of Prof. Boccaccini. The main purpose of this collaboration is to investigate the bioactivity of these novel composite structures (with and without niobium) that should lead to composite scaffolds with enhanced biological activity.

[1] A. R. Boccaccini, et al., Electrophoretic deposition of biomaterials, J. Royal Soc. Interface 7 S5 (2010) S581- S613.

[2] E.M Varoni, L. Altomare, A. Cochis, A. Ghalayaniesfahani, A. Cigada, L. Rimondini, L. De Nardo, Hierarchic micro-patterned porous scaffolds via electrochemical replica-deposition enhance neo-vascularization, Biomedical Materials 11 (2016) 025018.

[3] A. Hoppe, N.S. Güldal, A.R. Boccaccini, A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics, Biomaterials. 32 (2011) 2757-74.

[4] V. Miguez Pacheco, et al., Development and characterization of niobium-releasing silicate bioactive glasses for tissue engineering applications, J. Europ. Ceram. Soc. (2017) in press.