Preparation of multifunctional bioactive composite scaffolds for bone tissue engineering

 

Investigator: Emre Yavuz (Visiting PhD student, Institute of Natural and Applied Sciences-Akdeniz University, Turkey)

Emre Yavuz

 

Ulrich-Schalk-Straße 3
91056 Erlangen
Raum01.117

Tel.: (+49) 1590 8461 089 

Email: emre.y.yavuz@fau.de

 

Supervisor: Qaisar Nawaz, Prof. Dr. Ing. Aldo R. Boccaccini

 

This research project involves developing of bioactive composite scaffolds based on suitable inorganic materials and biodegradable polymers for bone tissue engineering and drug delivery function. In this scope firstly 45S5 bioactive glass scaffolds will be fabricated by the foam replica technique [1]. Afterwards mesoporous bioactive glasses will be synthesized by sol-gel technique. Then bioactive glass scaffolds are coated with the synthesized mesoporous bioactive glasses and a biodegradable polymer incorporating a model drug. The novel multifunctional composite scaffolds will be characterized in terms of microstructure, porosity, mechanical properties, bioactivity and drug releasing capability. The new family of scaffolds will be compared in their bioactivity and drug releasing ability with equivalent scaffold systems being developed by other members of the Institute of Biomaterials.

[1] Chen, Q.Z., I.D. Thompson, and A.R. Boccaccini, 45S5 Bioglass-derived glass-ceramic scaffolds for bone tissue engineering. Biomaterials, 2006. 27(11). 2414-25.