Electrospun film reinforced bioactive glass/polymer composite bone scaffolds: fabrication and degradation simulation


Investigator: Quan Shi (Visiting PhD student, Southeast University, Nanjing, China)

Quan Shi

Supervisor (Southeast University): Prof. Zhiyong Li
Supervisor (FAU): Prof. Aldo R. Boccaccini

Ulrich-Schalk-Straße 3
91056 Erlangen

room: 01.122

phone: (+49) 9131 85 69636

email: quan.shi@fau.de

Since the discovery of 45S5 Bioglass® by Larry Hench in 1971 [1], this material has been considered as a promising alternative material to regenerate, repair and replace the skeletal system due to its bone-bonding ability. With advanced properties similar to those of the native extracellular matrix, hydrogels have found widespread applications in tissue engineering. In this research, a combination of 45S5 Bioglass® scaffolds [2] and a hydrogel will be investigated to produce novel 3D scaffolds with enhanced osteoconductivity and biodegradability. In addition electrospun PCL membranes will be used to enhance the scaffold's compressive strength.

[1]. Hench L. L., Splinter R. J., Allen W. C., Grennlee T. K., Bonding Mechanisms at the Interface of Ceramic Prosthetic Materials, Journal of Biomedical Materials Research, 1971, 5(6): 117-141.

[2] Chen, Q. Z., Thompson, I. D., Boccaccini, A. R., 45S5 Bioglass®-derived glass–ceramic scaffolds for bone tissue engineering, Biomaterials 2006, 27 (11), 2414-2425.